Spravato®

When Traditional Treatments Haven't Worked, There's New Hope

Spravato® therapy for treatment-resistant depression

If you've tried multiple antidepressants without lasting relief, Spravato® offers a new path forward. This FDA-approved therapy works through a unique mechanism to provide rapid symptom relief, often within hours rather than weeks or months. 



Experience this revolutionary treatment in our comfortable, medically supervised setting where healing and hope come together. Weekend and evening hours are available to fit any schedule.

A Revolutionary Breakthrough in Depression Treatment

70 Years of the Same Approach. Until Now.

For the past seven decades, the field of mental health has relied on the same medications with the same statistical outcomes, demonstrating only a 1 in 4 chance of remission. Traditional antidepressants work by targeting serotonin, norepinephrine, or dopamine systems. But what if your depression stems from a different pathway entirely?


Spravato® represents the first truly innovative approach to depression treatment in generations. This cutting-edge advancement offers new doors to healing for patients who haven't responded to traditional therapies.

An image of someone receiving spravato care.

About Spravato®

What Makes Spravato® Different?

1. A New Neural Pathway:

Unlike traditional antidepressants, Spravato® (esketamine) works through the glutamate system in your brain. This completely different mechanism can provide relief when other treatments have failed.

2. Rapid Results:

Where conventional antidepressants may require weeks to take effect, Spravato® can reduce depressive symptoms within hours of administration.

3. Proven Effectiveness:

Clinical trials show that up to 33% of people with treatment-resistant depression experience significant improvement with Spravato® therapy.

4. FDA-Approved:

Specifically approved for treatment-resistant depression and depression with suicidal ideation.

How Spravato® Works: The Science of Hope

The Glutamate Connection

Your brain contains a complex network of chemical messengers called neurotransmitters. While traditional antidepressants focus on serotonin, Spravato targets the glutamate system, which plays a crucial role in learning, memory, and mood regulation.

The Process:
  • Esketamine increases glutamate activity in specific brain regions
  • Enhanced glutamate promotes the growth of new neural connections
  • These new pathways can help restore healthy brain function
  • The result: improved mood, reduced depressive symptoms, and renewed hope
Why This Matters for Treatment-Resistant Depression

If traditional antidepressants haven't worked for you, it may be because your depression involves the glutamate system rather than just serotonin pathways. Spravato addresses this different biological mechanism, offering relief where other treatments have fallen short.

Who Can Benefit from Spravato® Therapy

You May Be a Candidate If:
  • You've tried at least two different antidepressants without adequate relief
  • Your depression significantly impacts your daily life, relationships, or work
  • You're currently taking an oral antidepressant (Spravato is used alongside your current medication)
  • You're looking for faster relief than traditional medications provide
  • You've struggled with depression for months or years without lasting improvement
Conditions We Treat:
  • Treatment-Resistant Depression - Depression that hasn't responded to traditional treatments
  • Major Depressive Disorder with Suicidal Ideation - Severe depression with thoughts of self-harm
  • Chronic Depression - Long-term depression that interferes with quality of life
Image of Spravato product box.

Your Spravato Experience: Comfort, Safety, and Care

Once approved for treatment, here's what you can expect:

Before Your Session

During Your Treatment Session

After Your Session

Treatment Schedule:

A Process of Hope

This isn't a cure-all. It's a process. But it's a process that can truly transform lives when delivered with the right support and innovative treatment.

01

Initial Phase (Weeks 1-4)

  • Two sessions per week for comprehensive symptom relief
  • Rapid response assessment to track your progress
  • Dosage optimization based on your individual response
02

Mid-Treatment Assessment

At week 4, you'll meet with your provider to evaluate your progress and determine the optimal long-term treatment plan. This ensures your therapy is tailored to your specific needs and response.

03

PaySauce acquires Smoothpay

  • Once weekly sessions as symptoms improve
  • Continued monitoring of your progress and wellbeing
04

Maintenance Phase (Week 9+)

  • Weekly or bi-weekly sessions based on your response
  • Long-term wellness planning with your care team
  • Ongoing support for sustained improvement

Ready to Take the Next Step Toward Relief?

If traditional treatments haven't worked, Spravato® may offer the breakthrough you need.

Safety and Monitoring:

Health Assessment

Comprehensive Medical Oversight

Every Spravato session includes:

  • Pre-treatment health assessment
  • Blood pressure monitoring before, during, and after treatment
  • Continuous professional supervision throughout your session
  • Emergency protocols and trained medical staff on-site
  • Comfortable observation area for your 2-hour monitoring period

Managing Side Effects

The most common side effects are typically mild and temporary:

  • Mood changes (feeling happy, anxious, or euphoric)
  • Physical sensations (mild nausea, changes in blood pressure)
  • Dissociation (feeling detached from thoughts or surroundings)
  • Sleepiness or mild dizziness

These effects generally appear within 40 minutes and resolve within 2-4 hours. Our team is experienced in managing any discomfort and ensuring your safety throughout the process.

Healthy Habit - people outside

Why Choose HealthMates for Spravato® Therapy:

Specialized Expertise

Led by Steven Mates, PMHNP-BC, with over 35 years of mental health experience and specialized training in Spravato® therapy. Steven's passion for innovative treatments and deep understanding of treatment-resistant depression makes HealthMates the premier choice for Spravato in the Dayton area.

Proven Results

The right medications make it easier for you to help yourself. With Spravato's rapid and effective results, we open new doors to healing for those who need breakthrough treatment.

Exceptional Environment

  • Private treatment rooms designed for comfort and relaxation
  • Spa-like atmosphere that promotes healing
  • Flexible scheduling including evening and weekend hours
  • Streamlined processes that eliminate common healthcare barriers

Comprehensive Support

  • Insurance authorization assistance - we handle the paperwork
  • Pharmacy coordination with Matrix VIP, Genoa, or CVS Specialty
  • Personalized treatment planning based on your unique needs
  • Comfortable observation area for your 2-hour monitoring period

Getting Started: 
Your Path to a Renewed You

Step 1: Enrollment

Complete our comprehensive intake forms, including insurance information. Cash payment options are available if you prefer not to use insurance.

Step 2: Consultation

Meet with our team to assess your mental health history, current symptoms, and treatment history. We'll determine if Spravato® is the right option for your specific situation.

Step 3: Insurance Authorization

We handle all prior authorization paperwork with your insurance company, removing this common barrier to care.

Step 4: Pharmacy Coordination

Your medication is ordered through our specialized pharmacy partners and delivered directly to our office for your convenience.

Step 5: Treatment Begins

Start your Spravato® sessions in our comfortable, supportive environment with experienced medical supervision.

Step 6: Ongoing Care

Work with our team to develop a comprehensive long-term management plan that may include continued Spravato® therapy alongside other supportive treatments.

Frequently Asked Questions

Insurance and Payment Options?

How quickly will I see results?

Can I continue my other medications?

How long will I need treatment?

What if I've tried everything and nothing has worked?

Your Journey to Healing Starts Here

You've been strong for so long, trying different treatments and holding onto hope even when relief seemed impossible. Spravato® offers a scientifically proven, FDA-approved path forward for treatment-resistant depression. In our comfortable, supportive environment, you'll receive expert care from specialists who understand your journey and believe in your potential for healing.

This breakthrough treatment, combined with our compassionate approach, opens new doors to the life you deserve. You don't have to struggle alone anymore.

Remember: seeking help is a sign of strength, not weakness. You deserve relief, hope, and the chance to feel like yourself again. We're here to support you every step of the way.